Chlormadinone Acetate (CMA) Powder | Raw Potent Progesterone

Buy Chlormadinone Acetate (CMA) Powder Online China Manufacturer Raw Potent progesterone CAS 302-22-7

What is Chlormadinone Acetate?

Chlormadinone acetate (abbreviated as CMA) is a progestin and antiandrogen. It is used as a hormonal contraceptive in combination with estrogen and in the treatment of gynecological disorders. It is also used in the treatment of prostate cancer in Japan. CMA is the acetate ester of chlormadinone, which, in contrast to CMA, was never marketed.

Chlormadinone Acetate Chemical Profile

Synonyms: 17-(Acetyloxy)-6-chloropregna-4,6-diene-3,20-dione
CAS: 302-22-7
MF: C23H29ClO4
MW: 404.93
Standard: CP2000, JP13
Appearance: white crystalline powder
Assay: 99%
Usage: Orally active progesteron with antiandrogenic activity; has been used in combinations as an oral contraceptive. Progestogen; antineoplastic (hormonal)

Chlormadinone Acetate Certificate Of Analysis

Chlormadinone Acetate Effects

Chlormadinone acetate (CMA) is a derivative of naturally secreted progesterone that shows high affinity and activity at the progesterone receptor. It has an anti-estrogenic effect and, in contrast to natural progesterone, shows moderate anti-androgenic properties.

CMA acts by blocking androgen receptors in target organs and by reducing the activity of skin 5alpha-reductase. It suppresses gonadotropin secretion and thereby reduces ovarian and adrenal androgen production.

CMA shows high contraceptive efficacy by inhibiting ovulation due to its ability to suppress or disrupt endogenous gonadotropin secretion and, by this, inhibits follicular growth and maturation. In addition, it suppresses endometrial thickness and increases the viscosity of cervical mucus.

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