Supply Estrogen Progestogen Oral Contraceptive Ethinylestradiol Powder Online
What is Ethinylestradiol?
Ethinylestradiol (EE) is an estrogen medication which is used widely in birth control pills in combination with progestins. It is also occasionally used as a component of menopausal hormone therapy for the treatment of menopausal symptoms in combination with progestins.
In the past, EE was widely used alone for various indications such as the treatment of gynecological disorders and prostate cancer, but this is no longer the case. It is usually taken by mouth
Ethinylestradiol Chemical Profile
CAS No.: 57-63-6
MF: C20H24O2
MW: 296.4
EINECS: 200-342-2
MP: 182-183 °C(lit.)
storage temp.: -20°C Freezer
Appearance: White Crystalline Powder
Usage: estrogen, plus progestogen as oral contraceptive.
Ethinylestradiol Certificate Of Analysis
| Item |
Specification |
Results |
| Appearance |
White to creamy white, odorless, crystalline powder. |
white crystalline powder |
| Solubility |
Insoluble in water; soluble in alcohol, in chloroform, in ether, in vegetable oils, and in solutions of fixed alkali hydroxides. |
Conforms |
| Identification |
A:IR B:UV |
Conforms |
| Specific optical rotation |
-28°~ -29.5° |
-28.3° |
| Melting range |
180~186ºC |
182.5~185.3ºC |
| Loss on drying |
≤1.0% |
0.45% |
| Residual Solvents |
Acetone≤0.5% |
0.08% |
| Assay |
97.0~102.0% (on the dried basis) |
99.43% |
| Particle Size |
90% ≤10μ |
Conforms |
| Conclusion |
The product complies with specification in USP34 |
Ethinylestradiol VS Estradiol
Ethinylestradiol is an estrogen, or an agonist of the estrogen receptors. It is a synthetic derivative of the natural estrogen estradiol, and differs from estradiol in various ways. Compared to estradiol, Ethinylestradiol has greatly improved bioavailability when taken by mouth, is more resistant to metabolism, and shows relatively increased effects in certain parts of the body like the liver and uterus.
These differences make Ethinylestradiol more favorable for use in birth control pills than estradiol, though also result in an increased risk of blood clots and certain other rare adverse effects.
Ethinylestradiol Side Effects
The general side effects of EE include breast tenderness and enlargement, headache, fluid retention, and nausea among others.[9] In men, EE can additionally cause breast development, feminization in general, hypogonadism, and sexual dysfunction. Rare but serious side effects include blood clots, liver damage, and cancer of the uterus.
