USP38 Topical corticosteroid anti-inflammatory Drug Desonide Powder For Skin
What is Desonide?
Desonide (INN) is a low-potency topical corticosteroid anti-inflammatory. It is primarily used to treat atopic dermatitis (eczema), seborrheic dermatitis, contact dermatitis and psoriasis in both adults and children. It has a fairly good safety profile and is available as a cream, ointment, lotion.
Desonide Basic Information
English Synonyms: PREDNACINOLONE;DESONIDE;1,4-PREGNADIEN-11-BETA, 16-ALPHA, 17,21-TETROL-3,20-DIONE 16,17-ACETONIDE;(11b,16a)-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-pregna-1,4-diene-3,20-dione;16-alpha-hydroxyprednisole-16,17-acetonide;17-acetonide,16-alpha-hydroxy-prednisolone-1;d-2083;steroderm
CAS NO.: 638-94-8
Assay: 99%+
Molecular Formula:C24H32O6
Molecular Weight:416.51
Desonide Powder Certificate Of Analysis
| Product name |
Desonide |
| CAS No. |
14252-80-3 |
Outer Packing |
25KG/DRUM |
| Production date |
Jan. 5th. 2018 |
Shelf life |
Jan. 4th. 2020 |
| Standard adopted |
USP38 |
| Items of analysis |
Specification |
Results |
| Appearance |
White crystalline powder |
Complies |
| Solubility |
Soluble in chloroform,sparingly in ethanol and in acetone ,practically insoluble in water |
Complies |
| IdentifIcation |
A: IR |
Complies |
| B: HPLC |
Complies |
| Assay(HPLC) |
98.0%～102.0% |
99.8% |
| 16α-Hydroxyprednisolone |
not more than 0.15% |
Not detected |
| Prednisolone |
Prednisolone |
0.05% |
| Desonide glyoxal |
not more than 0.50% |
0.26% |
| Deoxyprednisolone-16-ene |
not more than 0.50% |
Not detected |
| Sum desonide glyoxal and deoxyprednisolone-16-en |
not more than 0.50% |
0.26% |
| Dihydrodesonide |
not more than 0.50% |
0.26% |
| Epoxydesonide |
not more than 0.50% |
Not detected |
| Sum of dihydrodesonide and epoxydesonide |
not more than 0.50% |
0.26% |
| Bromodesonide |
not more than 0.15% |
Not detected |
| Acetyldesonide |
not more than 0.15% |
0.05% |
| Any other impurity |
not more than 0.10% |
0.01% |
| Total impurities |
not more than 1.00% |
0.59% |
| Loss on drying |
≤ 0.5% |
0.09% |
| Optical rotation |
+104.0°～+ 110.0° |
+105.9° |
| Dichloromethane |
not more than 600ppm |
complies |
| Methanol |
not more than 3000ppm |
complies |
| Pyridine |
not more than 200ppm |
complies |
| Acetone |
not more than 5000ppm |
complies |
| Particle size |
100%≤30 microns |
complies |
| Residue on ignition |
≤0.1% |
0.03% |
| Conclusion |
Qualified |
Desonide Medical Uses
Desonide is a prescription topical treatment for redness, swelling, itching, and discomfort of various skin conditions. Regardless of the vehicle used, desonide is applied 2 to 3 times a day, at the same times each day. Skin conditions typically improve in the first two weeks of treatment. Patients are instructed to use desonide for the minimum amount of time necessary for conditions to improve.
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