Factory Direct Synthetic Corticosteroid Drug Raw Prednisone Powder
What is Prednisone?
Prednisone is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant drug. It is used to treat certain inflammatory diseases (such as moderate allergic reactions), some autoimmune diseases, and (at higher doses) some types of cancer, but it has significant adverse effects.
prednisone, a glucocorticoid, can improve renal responsiveness to atrial natriuretic peptide by increasing the density of natriuretic peptide receptor type A in the renal inner medullary collecting duct, inducing a potent diuresis.
Prednisone Basic Information
| CAS No. |
53-03-2 |
| Appearance and properties |
white crystalline powder |
| density |
1.3 g/cm3 |
| melting point |
236-238 C (lit.) |
| boiling point |
573 .7DHS C at 760 MMHG |
| flash point |
314.8 DHS C |
| refractive index |
170 (C = 0.5, Dioxane) |
| stability |
Stable. Incompatible with strong oxidizing agents |
| storage conditions |
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from Incompatible materials and ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage. |
Prednisone Certificate Of Analysis
| Product name |
Prednisone |
| CAS No. |
53-03-2 |
Outer Packing |
1KG/drum |
| Production date |
2018.01.12 |
Shelf life |
2021.01.11 |
| Standard adopted |
USP35 |
| Items of analysis |
Specification |
Results |
| Appearance |
White or almost white , crystalline powder |
almost white crystalline powder |
| Identification |
A:B |
Meets test |
| Specific optical rotation |
+167～+175° |
168° |
| Loss on drying |
≤1.0% |
0.1% |
| Water |
≤1% |
0.4% |
| Residue on ignition |
10mg |
Comply |
| Any other detected impurit |
≤1.5% |
0.93% |
| Total impurit |
≤2% |
1.16% |
| Assay |
97.0%～102.0% |
98.8% |
| Conclusion |
Qualified |
Prednisone Medical Uses
1)Prednisone is used for many different autoimmune diseases and inflammatory conditions, including: asthma, COPD, CIDP, rheumatic disorders, allergic disorders, ulcerative colitis and Crohn’s disease, adrenocortical insufficiency, hypercalcemia due to cancer, thyroiditis, laryngitis, severe tuberculosis, urticaria (hives), lipid pneumonitis, pericarditis, multiple sclerosis, nephrotic syndrome, sarcoidosis, to relieve the effects of shingles, lupus, myasthenia gravis, poison oak exposure, Ménière’s disease, autoimmune hepatitis, the Herxheimer reaction that is common during the treatment of syphilis, Duchenne muscular dystrophy, uveitis, and as part of a drug regimen to prevent rejection after organ transplant.
2) Prednisone can be used in the treatment of decompensated heart failure to increase renal responsiveness to diuretics, especially in heart failure patients with refractory diuretic resistance with large dose of loop diuretics. In terms of the mechanism of action for this purpose:
3) Prednisone has also been used in the treatment of migraine headaches and cluster headaches and for severe aphthous ulcer. Prednisone is used as an antitumor drug.[5] It is important in the treatment of acute lymphoblastic leukemia, non-Hodgkin lymphomas, Hodgkin’s lymphoma, multiple myeloma, and other hormone-sensitive tumors, in combination with other anticancer drugs.
