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Phenylephrine Hydrochloride Powder | Decongestant Raw Drug

» Solutions / Conversion Recipes » Phenylephrine Hydrochloride Powder | Decongestant Raw Drug

Phenylephrine Hydrochloride Powder | Decongestant Raw Drug

2018-01-12

Manufacturer Decongestant Raw Drug Phenylephrine Hydrochloride Powder

 

What is Phenylephrine hydrochloride?

Phenylephrine is a selective α1-adrenergic receptor agonist of the phenethylamine class used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood pressure.

Phenylephrine is marketed as an alternative for the decongestant pseudoephedrine, although clinical trials show phenylephrine, taken orally at the recommended dose, to be no more effective than placebo for allergy relief. Phenylephrine can also cause a decrease in heart rate through reflex bradycardia.

 

Phenylephrine hydrochloride Basic Information

CAS Number:61-76-7
uperlist Name:Phenylephrine hydrochloride
Formula:C9H14ClNO2
Molecular Weight:203.6
Synonyms:L(-)-Phenylephrine hydrochloride;(R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride;3-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol;
EINECS:200-517-3
Melting Point:143-145 °C(lit.)
Boiling Point:341.1 °C at 760 mmHg
Flash Point:163.4 °C
Appearance:white to almost white crystalline powder

 

 Phenylephrine hydrochloride Certificate of Analysis

Product name PHENYLEPHRINE HCL BP
CAS No. 61-76-7 Outer Packing 25KG/DRUM
Production date JULY 2017 Shelf life JUNE 2021
Standard adopted BP
Items of analysis Specification Results
description a white or almost white crystalline powder almost white powder
solubility freely soluble in water and in ethanol(96%) complies
melting point about 143℃ 143℃
identification
SOR(A) -43°to -47° -45.11°
IR(C) concordant with WS complies
chloride(E) solution responds to test for chloride complies
appearance of solution colution is clear and colorless complies
acidity or alkalinity not more than 0.4ml of 0.01M HCL is consumed complies
related substances(HPLC)
impurity C NMT 0.10% not detected
impurity E NMT 0.10% not detected
unspecified impurities NMT 0.10% 0.058%
total impurities NMT 0.20% 0.058%
loss on drying 105℃ NMT1.0% 0.21%
sulphate NMT 500ppm complies
sulphated ash NMT 0.10% 0.036%
assay(on dried basis) 98.5%-101.0% 99.81%
Conclusion Qualified

 

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