Buy CP 2010 Respiratory Drugs Raw APIs powder Zafirlukast (Accolate) Online
What is Zafirlukast?
Zafirlukast is an orally administered leukotriene receptor antagonist (LTRA) used for the chronic treatment of asthma.
While zafirlukast is generally well-tolerated, headache and stomach upset often occur. Some rare side effects can occur, which can be life-threatening, such as liver failure. Churg-Strauss syndrome has been associated with zafirlkast, but the relationship isn’t thought to be causative in nature. Overdoses of zafirlukast tend to be self-limiting.
Zafirlukast Basic Information
| Product Name |
Zafirlukast |
| CAS number |
107753-78-6 |
| Molecular formula |
C31H33N3O6S |
| Molecular weight |
575.68 |
| Melting Point |
139 C |
Zafirlukast Certificate Of Analysis
| Product Name |
Zafirlukast |
|
| CAS No. |
107753-78-6 |
Outer Packing |
25kg/Drum |
| Production date |
15th Jan 2018 |
Shelf life |
14th Jan 2023 |
| Standard Adopted |
CP 2010 |
| Items |
Specifications |
Results |
| Appearance |
White or light yellow powder |
White powder |
| Solubility |
Soluble in acetone,DMSO,HF; in soluble in water, methanol |
Complies |
| Identify 1 |
Maximum absorption wavelength: 240nm,300nm |
239nm,298nm |
| Identify 2 |
Content determination:conforms to spectrum |
Complies |
| Identify 3 |
IR: conforms to spectrum |
Complies |
| Chloride |
NMT 0.02% |
<0.02% |
| Sulfate |
NMT 0.04% |
<0.04% |
| Total impurities |
NMT 0.1% |
0.06% |
| Moisture |
NMT 1.0% |
0.38% |
| Loss on drying |
NMT 0.1% |
0.02% |
| Heavy metals |
NMT 20 ppm |
<20 ppm |
| Content |
98.5%~101.5%(based on dry) |
99.9% |
| Conclusion |
Conform to CP 2010 |
Zafirlukast Medical Uses
Zafirlukast is FDA-approved for the prevention and treatment of asthma in adults and children older than 5 years old. Like other leukotriene receptor antagonists, zafirlukast is thought to be useful for the long-term treatment of asthma, but it is generally less effective than inhaled glucocorticoids as monotherapy (which are the standard of care) or long-acting beta-2 agonists in combination therapy. Notably, zafirlukast is ineffective in the event of an acute asthma attack.
Zafirlukast Side Effects
Zafirlukast is generally well-tolerated, though headache and gastrointestinal (GI) upset can occur. GI upset may include nausea, stomach discomfort/pain, and diarrhea. GI complaints can be lessened by taking zafirlukast with food, though this can dramatically impair the amount of drug that gets absorbed into the body.
Other common side effects include flu-like symptoms, sleep disturbances (abnormal dreams, insomnia), hallucinations, and daytime drowsiness
