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Antiplatelet Drug Eptifibatide Acetate Peptide

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Lab Supply High Quality Antiplatelet Drug Eptifibatide Acetate Peptide

 

Eptifibatide Acetate Chemical Profile

Name: Eptifibatide Acetate, eptifibatida, Eptifibatid
Cas No:148031-34-9
Formula: C37H53N11O11S2
Molecular:892
Sequence:3-MERCAPTOPROPIONYL-HOMOARG-GLY-ASP-TRP-PRO-CYS-NH2 ACETATE SALT (DISULFIDE BOND)
Purity:98%
Appearance: white powder
Source: synthetic

 

What is Eptifibatide Acetate ?

Eptifibatide is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class.

Eptifibatide is a cyclic heptapeptide derived from a protein found in the venom of the southeastern pygmy rattlesnake (Sistrurus miliarius barbouri). It belongs to the class of the arginin-glycin-aspartat-mimetics and reversibly binds to platelets. Eptifibatide has a short half-life. The drug is the third inhibitor of GPIIb/IIIa that has found broad acceptance after the specific antibody abciximab and the non-peptide tirofiban entered the global market.

Integrilin is sold in two strengths, globally: vials containing 2 mg/ml (20 mg totally) and 0.75 mg/ml (75 mg totally). A third size is sold in the US: 100 ml vials containing 2 mg/ml (200 mg totally).

Eptifibatide Acetate Specification

Item

 Specification Result
Appearance White powder Complies
Identification Positive Complies
Assay 98.0% min 98.28%
Peptide content

80.0%min

 88.0%
Mass Balance 95.0-105.0% 98.0%
Acetic acid 3.0%-8.0% 4.2%
Loss on Drying 6.0%max. 5.7%
MeOH(GC) 0.3%max Complies
AcN(GC) 0.041%max Complies

 

Eptifibatide Acetate Application

1. Eptifibatide Acetate is used to reduce the risk of acute cardiac ischemic events (death and/or myocardial infarction) in patients with unstable angina or non-ST-segment-elevation (e.g., non-Q-wave) myocardial infarction (i.e., non-ST-segment elevation acute coronary syndromes) both in patients who are to receive non surgery (conservative) medical treatment and those undergoing percutaneous coronary intervention (PCI).

2. Eptifibatide Acetate is usually applied together with aspirin or clopidogrel and (low molecular weight or unfractionated) heparin. Additionally, the usual supportive treatment consisting of applications of nitrates, beta-blockers, opioid analgesics and/or benzodiazepines should be employed as indicated. Angiographic evaluation and other intensive diagnostic procedures may be considered a first line task before initiating therapy with eptifibatide.

3. Eptifibatide Acetate should exclusively be used in hospitalized patients both because of the serious degree of patients’ illness and because of the possible side-effects of eptifibatide.

 

Eptifibatide Acetate Dosage

The recommended adult dosage is an i.v. loading dose of 180 µg/kg over 1 to 2 minutes immediately after diagnosis, followed by continuous i.v.-infusion of 2 µg/kg per minute until either hospital discharge or initiation of coronary artery bypass grafting, or for up to 72 hours. At least 4 hours before discharge all local or systemic bleedings should have been controlled and terminated.

Patients weighing >120 kg should receive a maximum bolus of 22.6 mg followed by a maximum infusion rate of 15 mg/h. Patients with renal impairment evidenced by CrCl <50 ml/min should receive the standard 180 µg/kg loading dose followed by infusion at 1 µg/kg/min.

 

Peptides List

Notes: Click product to reach the product page

NO. Name Packing / CAS
T-A001 MGF 2mg / 5mg
T-A002 PEG MGF 2mg
T-A003 CJC-1295 with DAC 2mg
T-A004 CJC-1295 without DAC 2mg
T-A005 PT-141 (Brmelanotice) 10mg
T-A006 Melanotan-1 (MT-1) 10mg
T-A007 Melanotan-II (MT-2) 10mg
T-A008 GHRP-2 5mg / 10mg
T-A009 GHRP-6 5mg / 10mg
T-A0010 Ipamorelin 2mg
T-A0011 Hexarelin 2mg
T-A0012 Sermorelin 2mg
T-A0013 Oxytocin 1g / 2mg
T-A0014 TB500 2mg
T-A0015 Pentadecapeptide BPC 157 2mg
T-A0016 HGH Fragment 176-191 2mg / 5mg
T-A0017 IGF-1 LR3 0.1mg / 1mg
T-A0018 Triptorelin 2mg
T-A0020 Tesamorelin 2mg HIV
T-A0021 Gonadorelin 2mg / 10mg
T-A0022 DSIP 2mg
T-A0023 Selank 5mg
T-A0024 Epitalon 10mg
T-A0025 AOD-9604 2mg
T-A0026 ACE 031 1mg
T-A0027 GDF-8 (Myostatin) 1mg (-20ºC)
T-A0028 Thyrotropin TRH 1g
T-A0029 Follistatin 315 1mg (-20ºC)
T-A0030 Follistatin 344 1mg (-20ºC)
T-A0031 Deslorelin 20mg
T-A0032 Adipotide 2mg
T-A0033 Argireline 1g
T-A0034 nonapeptide-1 1g
T-A0035 SNAP-8 1mg
T-A0036 Alarelin Acetate 79561-22-1
T-A0037 Angiotensin Acetate 58-49-1
T-A0038 Argpressin Acetate 113-79-1
T-A0039 Aviptadil Acetate 40077-57-4
T-A0040 Bivalirudin Trifluoroacetate 128270-60-0
T-A0041 Deslorelin Acetate 57773-65-6
T-A0042 Desmopressin Acetate 16679-58-6
T-A0043 Eledoisin Acetate 69-25-0
T-A0044 Eptifibatide Acetate 148031-34-9
T-A0045 Felypressin Acetate 56-59-7
T-A0046 GLP-1 (7-37) Acetate 106612-94-6
T-A0047 Taspoglutide 275371-94-3
T-A0048 Glucagon Hydrochloride 16941-32-5
T-A0049 Lixisenatide 320367-13-3
T-A0050 Gonadorelin Acetate 34973-08-5
T-A0051 Leuprorelin Acetate 53714-56-0
T-A0052 Lysipressin Acetate 50-57-7
T-A0053 Nafarelin Acetate 76932-56-4
T-A0054 Octreotide Acetate 79517-01-4
T-A0055 Ornipressin Acetate 3397-23-7
T-A0056 Secretin Acetate 108135-74-8
T-A0057 Somatostatin Acetate 38916-34-6
T-A0058 Splenopentin Acetate 105184-37-0
T-A0059 Terlipressin Acetate 14636-12-5
T-A0060 Teriparatide Acetate 52232-67-4
T-A0061 Triptorelin Acetate 57773-63-4
T-A0062 Vasopressin Acetate 9034-50-8
T-A0063 Bate-Amyloid(1-42)human 107761-42-2
T-A0064 Abarelix Acetate 183552-38-7
T-A0065 Endothelin-1 Acetate 117399-94-7
T-A0066 CRF (human, rat) Acetate 86784-80-7
T-A0067 CRF (ovine) Trifluoroacetate 79804-71-0
T-A0068 Dynorphin A (1-13) Acetate 72957-38-1
T-A0069 Enfuvirtide Acetate (T-20) 159519-65-0
T-A0070 Fertirelin Acetate 38234-21-8
T-A0071 GRF (human) Acetate 83930-13-6
T-A0072 Liraglutide 204656-20-2
T-A0073 Dalmarelin Acetate 61012-19-9
T-A0074 Nesiritide Acetate (BNP-32) 114471-18-0
T-A0075 Pramlintide Acetate 196078-30-5
T-A0076 Salmon Calcitonin Acetate 47931-85-1
T-A0077 tesamorelin 106612-94-6
T-A0078 Tetracosactide Acetate (ACTH 1-24) 16960-16-0
T-A0079 Thymosin α1 Acetate 14636-12-5
T-A0080 Thymosin β4 Acetate 77591-33-4
T-A0081 Atosiban Acetate 90779-69-4
T-A0082 Cetrorelix Acetate 130143-01-0
T-A0083 Exenatide Acetate 141732-76-5
T-A0084 Histrelin Acetate 76712-82-8
T-A0085 Taltirelin Acetate 103300-74-9
T-A0086 Vapreotide Acetate 116430-60-5
T-A0087 Gonaderelin 33515-09-2
T-A0088 Cecropin B 80451-05-4
T-A0089 Oxytocin Acetate 50-56-6
T-A0090 Sincalide 25126-32-3
T-A0091 Protirelin 24305-27-9
T-A0092 Ganirelix acetate 123246-29-7

 

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