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Megestrol Acetate (MGA) Powder | Raw Progestin

» Hormone Powder » Female Hormones | Progestin » Megestrol Acetate (MGA) Powder | Raw Progestin

  • Specifications

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Whats is Megestrol Acetate?

Megestrol is a hormone therapy. It is classified as a “progesterone.”

Megestrol acetate (abbreviated as MGA), is a progestin with antiandrogen activity that is mainly used as an appetite stimulant and less commonly in the treatment of breast and endometrial cancers

 

Megestrol Acetate Chemical Profile

Synonyms: Nomegestrol Acetate; 17-hydroxy-6-methylpregna-4
CAS No.: 595-33-5
ECNECS No.: 209-864-5
MF: C24H32O4
MW: 384.5
Purity: 99%
Density: 1.15g/cm3
Melting Point: 214º C
Boiling Point: 507.1° Cat760mmHg
Refractive Index: 11 ° (C=2, CHCl3)
Flash Point: 218.5° C
Appearance: White or light yellow crystalline powder
Grade: Pharmaceutical Grade
Storage: Shading, confined preservation

 

Megestrol Acetate Certificate of Analysis

Test Items  Specification  Test Results
Appearance White to creamy white 
crystalline powder
White crystalline powder
Identification IR Complies
Completeness 
of solution
Meets the requirements.
500mg being 
Complies
 
Solubility
 
dissolved in 10ml of 
acetone
 
Complies
 
Insoluble in water, sparingly 
soluble in 
alcohol. Slightly soluble in 
ether and in 
fixed oils, soluble in acetone; 
very soluble
in chloroform.
Melting range 213ºC~220ºC  217ºC
Specific optical rotation +8.8°~ +12.0° +11.6°
Water ≤0.5% 0.1%
Residue roration ≤0.2% 0.06
Heavy metals ≤0.002% Complies
Assay 97.0%~103.0% 99.6%
Residual solvents
 
Methanol≤1000ppm 74ppm
Ethanol≤1000ppm 39ppm
Methylene chloride≤500ppm 28ppm
Tetrahydrofuran≤300ppm ND
Benzene≤2ppm ND
Conclusion Complies

 

Megestrol Acetate Application

1) Treatment of breast, and endometrial cancers.
2) Use as a supportive medication to treat severe loss of appetite (anorexia), muscle wasting (cachexia) and significant weight loss (> 10% of baseline body weight) associated with cancer and/or AIDS.

Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.

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