Buy USP36 Norethisterone (Norethindrone) Powder Online Raw Progestin Powder CAS 68-22-4
What is Norethisterone?
Norethisterone, also known as norethindrone, is a progestin medication which is used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders. The medication available in low-dose and high-dose formulations and is used alone or in combination with an estrogen. It is taken by mouth.
Norethisterone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has weak androgenic and estrogenic activity, mostly at high dosages, and no other important hormonal activity.
Norethindrone Quick detail
| Synonym |
ENT; NET; Norfor; sc4640; Anovule; Gestest |
| CAS NO |
68-22-4 |
| Molecular Formula |
C20H26O2 |
| Molecular weight |
298.42 |
| Purity |
>99% |
| Appearance |
Off-White to Pale Yellow Solid |
| Suitable for |
Adult |
| Standard |
USP36 |
| Usage |
Progesteron. Norethindrone and acetate in combination with estrogen as contraceptive (oral).
It is reasonably anticipated to be a human carcinogen |
| Packing |
Discreet packing ways as your requirement, 100%
go through. |
| Storage |
Store in cool and dry area and keep away from direct sunlight. |
Norethindrone COA:
| Product Name |
Norethindrone |
| Manufacturing Date |
2018.01.09 |
Batch No. 20170109 |
| Expiry Date |
2022.01.08 |
Report Date 2018.01.16 |
| Reference Standard |
USP36 |
| TEST |
ACCEPTANCE CRITERIONS |
|
RESULTS |
| Identification |
UV spectrum |
Positive |
|
IR spectrum |
Positive |
| Characteristics |
White to creamy white, odorless, crystalline powder. |
Pass |
|
Is stable in air. |
|
| Solubility |
Soluble in chloroform and in dioxane; sparingly soluble |
Pass |
|
in alcohol; slightly soluble in ether; practically insoluble in water. |
|
| Completeness of solution |
The solution called for in the test for Specific rotation is clear |
Pass |
|
and free from undissolved solid. |
|
| Melting point |
202 ~ 208℃ |
203~206.5℃ |
| Specific optical rotation |
﹣30° ～﹣38° |
﹣34.2° |
| Loss on drying |
≤0.5% |
0.20% |
| Limit of ethynyl group |
8.18%～8.43% |
8.30% |
| Assay |
97 .0~ 102.0% |
99.45% |
|
total impuritics≤1.5% |
|
| Related substances |
only one impurity≤0.5% |
Pass |
| Conclusion |
This batch complies with USP36 |
|
Norethisterone Medical uses
Norethisterone is used as a hormonal contraceptive in combination with an estrogen – usually ethinylestradiol (EE) – in combined oral contraceptive pills and alone in progestogen-only pills.
Norethisterone has also been shown to be effective in inhibiting leutinizing hormone and follicle-stimulating hormone secretion in men as well. Without these hormones, mature sperm cannot survive in the testes. This means that norethisterone could also be an effective male hormonal contraceptive.
Aside from its use as a contraceptive, norethisterone can be used to treat premenstrual syndrome, dysmenorrhea, menorrhagia, irregular menstruation, menopausal symptoms (in combination with estrogen), or to postpone a period. It is also commonly used to help prevent uterine hemorrhage in complicated non-surgical or pre-surgical gynecologic cases and in treating non responsive cyclical mastalgia.
Another medical use of norethisterone is to alleviate endometriosis related pain.
Norethisterone Side effects
Side effects of norethisterone include menstrual irregularities, headaches, nausea, breast tenderness, mood changes, acne, increased hair growth, and others.
