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Tiotropium Bromide (Spiriva) Powder | Anticholinergic Bronchodilator APIs

» Pharmaceutical » Respiratory System APIs » Tiotropium Bromide (Spiriva) Powder | Anticholinergic Bronchodilator APIs

  • Specifications

Buy Raw Anticholinergic Bronchodilator APIs Tiotropium bromide (Spiriva) Powder Online

 

What is Tiotropium bromide?

Tiotropium bromide, originally marketed as Spiriva,[1] is a long-acting, 24-hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD)

 

Tiotropium bromide Basic Information

Product Name Tiotropium bromide
CAS 136310-93-5
MF C19H22BrNO4S2
MW 472.42
Apperance White Solid
Usage Muscarinic receptor antagonist. Bronchodilator

 

Tiotropium bromide certifIcate Of Analysis

Product name Tiotropium bromide
CAS No. 136310-93-5 Outer Packing 1kg/bag
Production date 13th Jan 2018 Shelf life 12th Jan 2020
Standard adopted Enterprise Standard
Items of analysis Specification Results
Appearance White or yellowish white powder or crystal Conforms
Solubility Slightly soluble in water, soluble in methanol, insoluble in dichloromethane Conforms
Identification (1) IR infrared spectrum; (2) Typical reaction of bromide Conforms
Residue on ignition ≤0.1% 0.06%
Water ≤0.5% 0.36%
Impurity C ≤0.3% Conforms
Impurity F ≤0.15% Conforms
Impurities A,E ≤0.15% Conforms
Impurities G,H ≤0.1% Conforms
Unknown Impurities ≤0.1% Conforms
Total Impurities ≤0.3% 0.29%
Isomer ≤0.1% 0.09%
Assay ≥99.0% 99.71%
Graininess D100:≤20 µm Conforms
Conclusion Qualified

 

Tiotropium bromide Medical Uses

Tiotropium is used for maintenance treatment of chronic obstructive pulmonary disease (COPD) which includes chronic bronchitis and emphysema.[3] It is not however used for acute exacerbations

 

Tiotropium bromide side effects

dry mouth and/or throat irritation. Rarely (<0.1% of patients) treatment is associated with:urinary retention, constipation, acute angle closure glaucoma, palpitations (notably supraventricular tachycardia and atrial fibrillation) and/or allergy (rash, angioedema, anaphylaxis).

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