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Ethinyl Estradiol Powder | Estrogen (Oral Contraceptive)

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Supply Estrogen Progestogen Oral Contraceptive Ethinylestradiol Powder Online

 

What is Ethinylestradiol?

Ethinylestradiol (EE) is an estrogen medication which is used widely in birth control pills in combination with progestins. It is also occasionally used as a component of menopausal hormone therapy for the treatment of menopausal symptoms in combination with progestins.

In the past, EE was widely used alone for various indications such as the treatment of gynecological disorders and prostate cancer, but this is no longer the case. It is usually taken by mouth

 

Ethinylestradiol Chemical Profile

CAS No.: 57-63-6
MF: C20H24O2
MW: 296.4
EINECS: 200-342-2
MP: 182-183 °C(lit.)
storage temp.: -20°C Freezer
Appearance: White Crystalline Powder
Usage: estrogen, plus progestogen as oral contraceptive.

 

Ethinylestradiol Certificate Of Analysis

Item Specification Results
Appearance White to creamy white, odorless, crystalline powder. white crystalline powder
Solubility Insoluble in water; soluble in alcohol, in chloroform, in ether, in vegetable oils, and in solutions of fixed alkali hydroxides. Conforms
Identification A:IR B:UV Conforms
Specific optical rotation -28°~ -29.5° -28.3°
Melting range 180~186ºC 182.5~185.3ºC
Loss on drying ≤1.0% 0.45%
Residual Solvents Acetone≤0.5% 0.08%
Assay 97.0~102.0% (on the dried basis) 99.43%
Particle Size 90% ≤10μ Conforms
Conclusion The product complies with specification in USP34

 

Ethinylestradiol VS Estradiol

Ethinylestradiol is an estrogen, or an agonist of the estrogen receptors. It is a synthetic derivative of the natural estrogen estradiol, and differs from estradiol in various ways. Compared to estradiol, Ethinylestradiol has greatly improved bioavailability when taken by mouth, is more resistant to metabolism, and shows relatively increased effects in certain parts of the body like the liver and uterus.

These differences make Ethinylestradiol more favorable for use in birth control pills than estradiol, though also result in an increased risk of blood clots and certain other rare adverse effects.

 

Ethinylestradiol Side Effects

The general side effects of EE include breast tenderness and enlargement, headache, fluid retention, and nausea among others.[9] In men, EE can additionally cause breast development, feminization in general, hypogonadism, and sexual dysfunction. Rare but serious side effects include blood clots, liver damage, and cancer of the uterus.

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