Buy China Manufacturer Estrogen Female Steroid Hormone Estrone (Oestrone) Powder
What is Estrone?
Estrone (E1), also name oestrone, is a steroid, a weak estrogen, and a minor female sex hormone. It is one of three major endogenous estrogens, the others being estradiol and estriol. Estrone, as well as the other estrogens, are synthesized from cholesterol and secreted mainly from the gonads, though they can also be formed from adrenal androgens in adipose tissue. Relative to estradiol, both estrone and estriol have far weaker activity as estrogens.
Estrone is a white, odorless, solid crystalline powder, with a melting point of 254.5 °C (490 °F) and a specific gravity of 1.23.[12][13] Estrone is combustible at high temperatures, with the products carbon monoxide (CO) and carbon dioxide (CO2).
Estrone Chemical Profile
CAS No: 53-16-7
Formula: C18 H22 O2
Melting Point: 260˚C
Molecular Weight: 270.37
Rotation: +162˚ Diox
Estrone Specification
| Test Items |
Specification |
Test Results |
| Description |
White or almost white crystalline powder |
White crystalline powder |
| Melting Point |
191.0~193.0ºC |
192ºC |
| Loss of drying |
≤1.0% |
0.5% |
| Heavy Metal |
≤20ppm |
15ppm |
| TLC |
Only one spot |
Only one spot |
| Assay |
≥99.5% |
99.91% |
| Conclusion |
It complies with the USP 32 |
Estrone Medical use
Estrone was previously marketed in intramuscular and vaginal formulations and was used as an estrogen in the treatment of symptoms of hypoestrogenism such as hot flashes and atrophic vaginitis in menopausal or ovariectomized women. It has since been discontinued and is no longer available, having been superseded by other estrogens with greater potency and improved pharmacokinetics (namely oral bioavailability and duration).
Although estrone itself is no longer used medically, other marketed estrogens such as estradiol and estrone sulfate produce estrone as a major metabolite.
