99.6% Purity Quality Corticosteroid Raw Material Flumetasone Powder
What is Flumetasone?
Flumetasone also known as flumethasone is a corticosteroid for topical use. It is for the treatment of otitis externa and otomycosis. It is usually formulated as the pivalic acid ester prodrug flumetasone pivalate.
Flumethasone is 420 times as potent as cortisone in an animal model for anti-inflammatory activity.
Flumetasone Basic Information
Synonyms: CORTEXILAR; FLUCORT; FLUMETHASON; ANIPRIME
CAS: 2135-17-3
EINECS: 218-370-9
Assay: 99% min.
Standard: BP/EP/USP
Packing: 1 kg/foil bag or tin.
Character: White or white crystalline powder.
Usage A glucocorticoid. An anti-inflammatory.
Flumetasone Certificate Of Analysis
| Product name |
Flumetasone |
| CAS No. |
2135-17-3 |
Outer Packing |
1kg |
| Production date |
11th Jan 2018 |
Shelf life |
10th Jan 2021 |
| Standard adopted |
Enterprise Standard |
| Items of analysis |
Specification |
Results |
| Appearance |
White crystalline powder |
complies |
| Identification(HPLC) |
Complies with the standard |
complies |
| Specific optical rotation |
+66º~+74º |
+71.9º |
| Loss on drying |
not more than 0.5% |
0.06% |
| Impurity at RRT 1.11 |
not more than 0.15% |
0.14% |
| Impurity at RRT 1.39 |
not more than 0.15% |
0.06% |
| Any unknoen Impurity |
not more than 0.2% |
0.06% |
| Total impurities |
not more than 1.0% |
0.37% |
| Purity |
no less than 99.0% |
99.6% |
| Conclusion |
Qualified |
Flumetasone Biochem/physiol Actions:
Flumethason is a glucocorticoid receptor agonist used in studies on plasma transcortin binding. It binds to the nucleus causing a variety of genetic activation and repressions. The anti-inflammatory actions of flumethason is thought to involve lipocortins and phospholipase A2 inhibitory proteins, which results in the inhibition of arachidonic acid and the control of prostaglandin and leukotriene biosynthesis.
Flumethason suppresses the immune system due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.
Flumetasone SIDE EFFECTS
Stinging during use may occur. If this reaction persists or worsens, notify your doctor. Tell your doctor immediately if any of these serious side effects occur: rash, redness, itching, swelling, severe pain of the ear. Tell your doctor immediately if any of these unlikely but serious side effects occur: vision problems, headache, increased thirst, increased urination. If you notice other effects not listed above, contact your doctor or pharmacist.
