Manufacturer EP6 Synthetic Glucocorticoid Corticosteroid Hydrocortisone Acetate Powder
What is Hydrocortisone acetate?
Hydrocortisone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester.
Hydrocortisone acetate Basic Information
Appearance:white powder
Synonyms:Cortacream;Cortaid;Cortef acetate;Cortell;Corticaine;Cortifoam;Cortril acetate;Cortril acetate AS;Efcolin;HA;Hc 45;Hycortole acetate;Hydrocort acetate;Hydrocortisat;Hydrocortisone 21-acetate;Cortisolacetate (6CI);Cortisol, 21-acetate (7CI,8CI);11b,17a,21-Trihydroxypregn-4-ene-3,20-dione21-acetate;17-Hydroxycorticosterone 21-acetate;17a-Hydroxycorticosterone acetate;21-Acetoxy-11b,17-dihydroxypregn-4-en-3,20-dione;21-Acetoxy-11b,17-dihydroxypregn-4-ene-3,20-dione;21-Acetoxy-11b,17a-dihydroxypregn-4-ene-3,20-dione;Abbocort;Anusol HC;Bambicort;Berlison F;Biocortar;CaldeCort;Chemysone;Colifoam;Colofoam;Cordes;
CAS Number: 50-03-3
Formula: C23H32O6
Molecular Weight: 404.50
EINECS:200-004-4
Package : 25kg/carton, or at customer’s requirements Storage: Store in a cool, dry place and keep away from direct strong light.50-03-3
Shelf Life :2 years
Hydrocortisone acetate Certificate of Analysis
| ITEMS |
SPECIFICATION |
RESULTS |
| CHARACTERS |
A WHITE OR ALMOST WHITE,
CRYSTALLINE POWDER |
WHITE CRYSTALLINE POWDER |
| SOLUBILITY |
PRACTICALLY INSOLUBLE IN WATER,
SPARINGLY SOLUBLE IN ETHANOL
AND IN METHYLENE CHLORIDE |
COMPLIES |
| MELTING POINT(PH.EUR.) |
ABOUT 220°C |
223°C |
| IDENTIFICATION |
| A.IR-SPECTRUM(PH.EUR) |
MEETS THE REQUIREMENT |
COMPLIES |
| B.TLC(PH.EUR) |
MEETS THE REQUIREMENT |
COMPLIES |
| A.IR-SPECTRUM(USP) |
MEETS THE REQUIREMENT |
COMPLIES |
| B.UV ABSORPTION(USP) |
MEETS THE REQUIREMENT |
COMPLIES |
| SPECIFIC ROTATION |
| (PH.EUR) |
BETWEEN+158°AND +167° |
+164.7° |
| (USP) |
BETWEEN+158°AND +165° |
+160.3° |
| LOSS ON DRYING |
| (PH.EUR) |
NOT MORE THAN 0.5% |
0.21% |
| (USP) |
NOT MORE THAN 1.0% |
0.16% |
| RESIDUE ON IGNITION(USP) |
NEGLIGIBLE,FROM 100mg |
COMPLIES |
| RELATED SUBSTANCES(PH.EUR) |
| ANY INDIVIDUAL IMPURITY |
NOT MORE THAN 1.0% |
0.16% |
| SUM OF IMPURITIES |
NOT MORE THAN 1.5% |
0.55% |
| CHROMATOGRAPHIC PURITY(USP) |
| ANY INDIVIDUAL IMPURITY |
NOT MORE THAN 1.0% |
0.12% |
| SUM OF IMPURITIES |
NOT MORE THAN 2.0% |
0.64% |
| RESIDUAL SOLVENT(IN-HOUSE) |
| ETHANOL |
NOT MORE THAN 2000PPM |
817PPM |
| DMF |
NOT MORE THAN 880PPM |
N.D. |
| ASSAY |
| (PH.EUR) |
BETWEEN 97.0% AND 103.0% |
100.6% |
| (USP) |
BETWEEN 97.0% AND 102.0% |
100.6% |
| PARTICLE SIZE(IN-HOUSE) |
90% NOT MORE THAN 20 MICRONS |
COMPLIES |
| CONCLUSION:THE PRODUCT CONFORMS TO PH.EP.6 |
Hydrocortisone acetate Usage
Hydrocortisone acetate is mainly used to treat rheumatoid arthritis, rheumatic fever, gout, bronchial asthma. Injection for tuberculous or fester sex meningitis, tuberculosis pleurisy, pyothorax, arthritis, tenosynovitis, tendons strain, sprains, nodular rash, itching flat moss, etc. Eye drops agent used in all kinds of eye inflammation. Frost agent in allergic or seborrheic dermatitis, itch disease, etc.
