Buy Imipenem (Primaxin) Powder Raw APIS Intravenous β-lactam Antibiotic Online CAS 74431-23-5
Imipenem Specification
Product Name: Imipenem
CAS: 74431-23-5
Natural/Synthetic: Synthetic
Source: Imipenem Crude Product
Storage: 0-20°C, lined with plastic bag, sealed with aluminum foil bag.
Level: Pharmaceutical grade
Content: 90%
Appearance: white powder
Packing: 1KG/aluminum foil bag
Ingredients: (5R, 6S)-6-[(1R)-1-hydroxyethyl]-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-1 -Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate
Physical and chemical properties: Characters: white or almost white powder Content: 97% or more Packaging: aluminum foil bag.
Category: Pharmaceutical Raw Materials
Field: β-lactam antibiotics
Deferred products: This product is crude, but also need refined talents for the drug substance
Use: Especially suitable for mixed infections caused by a variety of pathogens and aerobic / anaerobic bacteria, as well as early treatment before the pathogen is determined. This product is used for all kinds of infections caused by sensitive bacteria, especially for a variety of bacterial infections and mixed infections of aerobic and anaerobic bacteria, such as peritonitis, hepatobiliary infection, intra-abdominal abscess, appendicitis, gynecological infections, lower respiratory tract Infections, skin and soft tissue infections, urinary tract infections, bone and joint infections, and sepsis.
Usage and dosage: After finished product is made, it is injected intramuscularly or intravenously, and the dose is based on imipenem. Adults, 1g to 2g/day, 2 to 4 times. For intramuscular injection, a suspension of 1% lidocaine can be used to reduce pain. Intravenous, can be diluted with saline or 5% glucose dissolved, dubbed 5mg/ml concentration, slow intravenous infusion. Children daily 60mg ~ 100mg/kg, points 3 to 4 times.
What is Imipenem?
Imipenem (Primaxin) is an intravenous β-lactam antibiotic. Carbapenems are highly resistant to the β-lactamase enzymes produced by many multiple drug-resistant Gram-negative bacteria, thus play a key role in the treatment of infections not readily treated with other antibiotics.
Imipenem has a broad spectrum of activity against aerobic and anaerobic, Gram-positive and Gram-negative bacteria. It is particularly important for its activity against Pseudomonas aeruginosa and the Enterococcus species. It is not active against MRSA, however.
Imipenem Certificate of Analysis
| Product name |
Imipenem |
| CAS No. |
74431-23-5 |
Outer Packing |
1KG/Durg |
| Production date |
20150903 |
Shelf life |
2017.09.02 |
| Standard adopted |
QB |
| Items of analysis |
Specification |
Results |
| Appearance |
Yellow to yellow-brownish powder |
light yellow crystalline powder |
| Identification |
1) Comparable IR spectra (minima/ maxima) of test and reference substances |
1) Comparable IR spectra (minima/ maxima) of test and reference substances |
| Identification |
1) Comparable IR spectra (minima/ maxima) of test and reference substances |
2) Conforms the requirement |
| PH |
Between 4.5 to 7.5 |
6.4 |
| Specific optical rotation |
Between +84 to +94˚ on anhydrous basis |
+86.0˚ |
| Sulphated ash |
Not more than 0.5% |
0.10% |
| Assay |
Not less than 95.0% on anhydrous basis |
96.01% |
| Related substances（1） |
1) Thienamycin : Not more than 1.0 area-% |
1)Thienamycin :0.63% |
| Related substances（2） |
2) Other individual impurities: Not more than 0.5 area-% |
2)Other individual impurities：＜0.5% |
| Related substances（3） |
3) Total impurities(other than Thienamycin): Not more than 1.0 area-% |
3)Total impurities：0.64% |
| Color value |
Not more than 170 (sample filtered, through 0.45um filter paper) |
31 |
| Bacterial endotoxins |
Not more than 0.17 EU/mg |
＜0.17 EU/mg |
| Water |
5.0%–8.0% |
7.7 |
| Conclusion |
Qualified |
Imipenem Mechanism of action
Imipenem acts as an antimicrobial through inhibiting cell wall synthesis of various Gram-positive and Gram-negative bacteria. It remains very stable in the presence of β-lactamase (both penicillinase and cephalosporinase) produced by some bacteria, and is a strong inhibitor of β-lactamases from some Gram-negative bacteria that are resistant to most β-lactam antibiotics.
Imipenem Adverse effects
Common adverse drug reactions are nausea and vomiting
