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Imipenem (Primaxin) Powder Raw APIS Intravenous β-lactam Antibiotic

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Buy Imipenem (Primaxin) Powder Raw APIS Intravenous β-lactam Antibiotic Online CAS 74431-23-5

 

Imipenem Specification

Product Name: Imipenem
CAS: 74431-23-5
Natural/Synthetic: Synthetic
Source: Imipenem Crude Product
Storage: 0-20°C, lined with plastic bag, sealed with aluminum foil bag.
Level: Pharmaceutical grade
Content: 90%
Appearance: white powder
Packing: 1KG/aluminum foil bag
Ingredients: (5R, 6S)-6-[(1R)-1-hydroxyethyl]-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-1 -Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate
Physical and chemical properties: Characters: white or almost white powder Content: 97% or more Packaging: aluminum foil bag.
Category: Pharmaceutical Raw Materials
Field: β-lactam antibiotics
Deferred products: This product is crude, but also need refined talents for the drug substance
Use: Especially suitable for mixed infections caused by a variety of pathogens and aerobic / anaerobic bacteria, as well as early treatment before the pathogen is determined. This product is used for all kinds of infections caused by sensitive bacteria, especially for a variety of bacterial infections and mixed infections of aerobic and anaerobic bacteria, such as peritonitis, hepatobiliary infection, intra-abdominal abscess, appendicitis, gynecological infections, lower respiratory tract Infections, skin and soft tissue infections, urinary tract infections, bone and joint infections, and sepsis.
Usage and dosage: After finished product is made, it is injected intramuscularly or intravenously, and the dose is based on imipenem. Adults, 1g to 2g/day, 2 to 4 times. For intramuscular injection, a suspension of 1% lidocaine can be used to reduce pain. Intravenous, can be diluted with saline or 5% glucose dissolved, dubbed 5mg/ml concentration, slow intravenous infusion. Children daily 60mg ~ 100mg/kg, points 3 to 4 times.

 

What is Imipenem?

Imipenem (Primaxin) is an intravenous β-lactam antibiotic. Carbapenems are highly resistant to the β-lactamase enzymes produced by many multiple drug-resistant Gram-negative bacteria, thus play a key role in the treatment of infections not readily treated with other antibiotics.

Imipenem has a broad spectrum of activity against aerobic and anaerobic, Gram-positive and Gram-negative bacteria. It is particularly important for its activity against Pseudomonas aeruginosa and the Enterococcus species. It is not active against MRSA, however.

 

Imipenem Certificate of Analysis

Product name Imipenem
CAS No. 74431-23-5 Outer Packing 1KG/Durg
Production date 20150903 Shelf life 2017.09.02
Standard adopted QB
Items of analysis Specification Results
Appearance Yellow to yellow-brownish powder light yellow crystalline powder
Identification 1) Comparable IR spectra (minima/ maxima) of test and reference substances 1) Comparable IR spectra (minima/ maxima) of test and reference substances
Identification 1) Comparable IR spectra (minima/ maxima) of test and reference substances 2) Conforms the requirement
PH Between 4.5 to 7.5 6.4
Specific optical rotation Between +84 to +94˚ on anhydrous basis +86.0˚
Sulphated ash Not more than 0.5% 0.10%
Assay Not less than 95.0% on anhydrous basis 96.01%
Related substances(1) 1) Thienamycin : Not more than 1.0 area-% 1)Thienamycin :0.63%
Related substances(2) 2) Other individual impurities: Not more than 0.5 area-% 2)Other individual impurities:<0.5%
Related substances(3) 3) Total impurities(other than Thienamycin): Not more than 1.0 area-% 3)Total impurities:0.64%
Color value Not more than 170 (sample filtered, through 0.45um filter paper) 31
Bacterial endotoxins Not more than 0.17 EU/mg <0.17 EU/mg
Water 5.0%–8.0% 7.7
Conclusion Qualified

 

Imipenem Mechanism of action

Imipenem acts as an antimicrobial through inhibiting cell wall synthesis of various Gram-positive and Gram-negative bacteria. It remains very stable in the presence of β-lactamase (both penicillinase and cephalosporinase) produced by some bacteria, and is a strong inhibitor of β-lactamases from some Gram-negative bacteria that are resistant to most β-lactam antibiotics.

 

Imipenem Adverse effects

Common adverse drug reactions are nausea and vomiting

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