Buy USP34 Paclitaxel Raw APIS Cancer Drugs Chemotherapy Medication CAS 33069-62-4 Online
Paclitaxel Specification
Product Name: Paclitaxel
CAS:33069-62-4
Standard: USP34
Level: Pharmaceutical grade
Content: 99%
Appearance: white powder
Packing: 1KG/aluminum foil bag
Physicochemical properties: This product is a white or white powder, highly lipophilic, insoluble in water. The melting point is about 216-217°C.
Category: Pharmaceutical Raw Materials
Field: Anti-tumor > Breast Cancer
Use: 1. This product is suitable for the treatment of patients with metastatic ovarian cancer failure or multiple chemotherapy failure first-line chemotherapy. 2. This product is suitable for the treatment of metastatic breast cancer failure of comprehensive chemotherapy or recurrence of breast cancer within six months after adjuvant chemotherapy.
Usage and dosage: This product concentrate injection must be diluted before infusion. Paclitaxel should be diluted in 0.9% Sodium Chloride Injection (USP), or in 5% Glucose Injection (USP), or in 5% Glucose plus 0.9% Sodium Chloride Injection (USP), to a final concentration of 0.3. -1.2mg/ml. Adult dosage, intravenously 135mg/m2 according to dose 24 hours every three weeks
What is Paclitaxel?
Paclitaxel (Taxol) is a chemotherapy medication used to treat a number of types of cancer. This includes ovarian cancer, breast cancer, lung cancer, Kaposi sarcoma, cervical cancer, and pancreatic cancer.
Paclitaxel Certificate of Analysis
| Product name |
PACLITAXEL |
| CAS No. |
33069-62-4 |
Outer Packing |
10g/5g/foli bag |
| Production date |
2018.2.12 |
Shelf life |
2020.2.11 |
| Standard adopted |
USP34 |
| Items of analysis |
Specification |
Results |
| ASSAY (calculated on the anhydrous, solvent-free basis) |
97.0%～102.0% |
99.7% |
| SPECIFIC ROTATION |
-49.0°～-55.0° |
-51.4° |
| IDENTIFICATION |
IR Infrared Absorption:In accordance with the reference Standard spectrum of paclitaxel |
Conforms |
| RELATED COMPOUNDS |
|
|
| Baccatin III |
NMT 0.2% |
0.08% |
| 10-Deacetylbaccatin III |
NMT 0.1% |
Undetected |
| Photodegradant |
NMT 0.1% |
Undetected |
| 10,13-Bissidechainpaclitaxel |
NMT 0.5% |
Undetected |
| 7-Acetylpaclitaxel |
NMT 0.6% |
Undetected |
| 7-Tes-paclitaxel |
NMT 0.3% |
Undetected |
| 13-Tes-baccatin III |
NMT 0.1% |
Undetected |
| 7-Epipaclitaxel |
NMT 0.4% |
0.09% |
| 2-Debenzoylpaclitaxel-2-pentenoate |
NMT 0.7% |
Undetected |
| 10-Deacetyl-7-cpipaclitaxel |
NMT 0.4% |
0.03% |
| Others |
NMT 0.1% (each) |
0.04% |
| Total |
NMT 2.0% |
0.28% |
| ORGANIC VOLATILE IMPURITIES |
|
|
| Acetone |
NMT 5000ppm |
33 ppm |
| n-heptane |
NMT 5000ppm |
Conforms |
| Dichloromethane |
NMT 600ppm |
Conforms |
| WATER |
NMT 4.0% |
0.50% |
| RESIDUE ON IGNITION |
NMT 0.2% |
0.06% |
| HEAVY METALS |
NMT 0.002% |
Conforms |
| BACTERIAL ENDOTOXINS |
NMT 0.4 EU/mg |
Conforms |
| MICROBIAL LIMITS |
Total aerobic microbial count NMT100 cfu/g |
1 cfu/g |
| Salmonella species, |
It meets the requirements of the tests for the absence of Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella species, and Escherichia coli |
Undetected |
| CONCLUSION |
The product is in accordance withUSP34 to test the above-mentioned items, |
conform to the specification |
| Conclusion |
Qualified |
Paclitaxel Side Effects
Common side effects include hair loss, bone marrow suppression, numbness, allergic reactions, muscle pains, and diarrhea. Other serious side effects include heart problems, increased risk of infection, and lung inflammation. There are concerns that use during pregnancy may cause birth defects.
Paclitaxel is in the taxane family of medications. It works by interference with the normal function of microtubules during cell division.
