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» Solutions / Conversion Recipes » Phenylephrine Hydrochloride Powder | Decongestant Raw Drug
Phenylephrine Hydrochloride Powder | Decongestant Raw Drug
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Manufacturer Decongestant Raw Drug Phenylephrine Hydrochloride Powder
What is Phenylephrine hydrochloride?
Phenylephrine is a selective α1-adrenergic receptor agonist of the phenethylamine class used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood pressure.
Phenylephrine is marketed as an alternative for the decongestant pseudoephedrine, although clinical trials show phenylephrine, taken orally at the recommended dose, to be no more effective than placebo for allergy relief. Phenylephrine can also cause a decrease in heart rate through reflex bradycardia.
Phenylephrine hydrochloride Basic Information
CAS Number:61-76-7
uperlist Name:Phenylephrine hydrochloride
Formula:C9H14ClNO2
Molecular Weight:203.6
Synonyms:L(-)-Phenylephrine hydrochloride;(R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride;3-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol;
EINECS:200-517-3
Melting Point:143-145 °C(lit.)
Boiling Point:341.1 °C at 760 mmHg
Flash Point:163.4 °C
Appearance:white to almost white crystalline powder
Phenylephrine hydrochloride Certificate of Analysis
| Product name | PHENYLEPHRINE HCL BP | ||
| CAS No. | 61-76-7 | Outer Packing | 25KG/DRUM |
| Production date | JULY 2017 | Shelf life | JUNE 2021 |
| Standard adopted | BP | ||
| Items of analysis | Specification | Results | |
| description | a white or almost white crystalline powder | almost white powder | |
| solubility | freely soluble in water and in ethanol(96%) | complies | |
| melting point | about 143℃ | 143℃ | |
| identification | |||
| SOR(A) | -43°to -47° | -45.11° | |
| IR(C) | concordant with WS | complies | |
| chloride(E) | solution responds to test for chloride | complies | |
| appearance of solution | colution is clear and colorless | complies | |
| acidity or alkalinity | not more than 0.4ml of 0.01M HCL is consumed | complies | |
| related substances(HPLC) | |||
| impurity C | NMT 0.10% | not detected | |
| impurity E | NMT 0.10% | not detected | |
| unspecified impurities | NMT 0.10% | 0.058% | |
| total impurities | NMT 0.20% | 0.058% | |
| loss on drying 105℃ | NMT1.0% | 0.21% | |
| sulphate | NMT 500ppm | complies | |
| sulphated ash | NMT 0.10% | 0.036% | |
| assay(on dried basis) | 98.5%-101.0% | 99.81% | |
| Conclusion | Qualified | ||