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Piperaquine Phosphate Powder Raw Antiparasitic Drug

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Buy Piperaquine Phosphate Powder Raw Antiparasitic Drug Online CAS 4085-31-8

 

Piperaquine phosphate Specification

Product Name: Piperaquine Phosphate
CAS: 4085-31-8
Level: Pharmaceutical Grade
Content: 98%
Appearance: Yellowish powder
Packing: 25kg/cardboard drum
Category: Pharmaceutical Raw Materials
Industry: Pharmaceuticals
Field: Antimalarial drugs
Deferred Products: Piperaquine Phosphate Tablets
Use: For the treatment of malaria, but also for the prevention of symptom inhibition. Especially for the treatment and prevention of falciparum malaria caused by chloroquine-resistant strains. Can also be used to treat silicosis
Usage and Dosage: 1 For the first time to treat malaria 0.5g, every 8 to 12 hours after serving 0.25g ~ 0.5g, the total amount of 0.75g ~ 1g. 2 Malaria prevention Once a month, take 0.5g and take it before going to bed. Can be used for 3 to 4 months, not more than 6 months. 3 The prevention and treatment of silicosis The prevention dose is 0.5g/time, 10~15 days, 1 month, January 1g~1.5g. Treatment volume 0.5g ~ 0.75g / time, 1 time / week, January 2g, half a year course of treatment; interval 1 month after the second course of treatment. The total course of treatment is about 3 to 5 years.

 

What is Piperaquine?

Piperaquine is an antiparasitic drug used in combination with dihydroartemisinin to treat malaria. Due to widespread parasite resistance to piperaquine, the drug fell out of use as a monotherapy, and is instead used as a partner drug for artemisinin combination therapy. Piperaquine kills parasites by disrupting the detoxification of host heme.

 

Piperaquine phosphate Certificate of Analysis

Product name Piperaquine phosphate
CAS No. 4085-31-8 Outer Packing 25kg/drum
Production date 2016-09-10 Shelf life 2018-09
Standard adopted Chinese Pharmacopoeia Standard 2010 Testing Standard
Items of analysis Specification Results
Character White to pale yellow crystalline powder, odorless, slightly bitter, easy to change color in case of light Conforms
Solubility Slightly soluble in water, almost insoluble in ethanol or chloroform Conforms
Melting point 246-252℃ 248.5℃
Identification (1) Precipitation reaction In the case of ammonium thiocyanate, a white precipitate is formed, and a yellow precipitate is formed in the presence of potassium hydroxide. Conforms
(2) UV-visible spectrophotometry Maximum absorption at 226 nm, 240 nm, and 347 nm Conforms
(3) Infrared spectra The infrared absorption spectrum of this product should be consistent with the reference map Conforms
(4) Phosphate identification Phosphate identification reaction Conforms
PH 3.0-4.0 3.26
Relative substance Total impurities《6.0% 0.33%
Water 6.0%-8.0% 7.40%
Assay (dried product meter) 》98.0% 98.9%
Conclusion Qualified

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