Buy China Local Anaesthetic Agent Procainamide Hydrochloride HCl Powder
What is Procainamide Hydrochloride?
Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to and blocks activated (open) voltage-gated sodium channels, thereby blocks the influx of sodium ions into the cell, which leads to an increase in threshold for excitation and inhibit depolarization during phase 0 of the action potential. In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, resulting in decreased impulse conduction velocity. The lasting action potential may also be due to blockage of outward K+ currents. The result is a decrease in automaticity, increase in refractory period and slowing of impulse conduction.
Procainamide Hydrochloride Basic Info
CAS: 614-39-1
MF: C13H22ClN3O
MW: 271.79
EINECS: 210-381-7
Appearance: white powder
Package: 25kg/drum
Assay: 99%
Grade: medical grade
Use: For ventricular arrhythmias and local anesthesia
Procainamide Hydrochloride Certificate Of Analysis
| Product name |
Procainamide hydrochloride |
| CAS No. |
614-39-1 |
Outer Packing |
25KG/DRUM |
| Production date |
2018.01.02 |
Shelf life |
2020.01.01 |
| Standard adopted |
USP 38 |
| Items of analysis |
Specification |
Results |
| Appearance |
A white or almost white crystalline |
Complies |
| Identification |
A.B in pass |
Complies |
| Melting Point |
165°~169° |
166°~169° |
| Solution trasparence |
50mg/mL colourless liquid |
colourless liquid |
| Organic volatile impurities |
Meets the requirements |
Complies |
| Limit of free p-aminobenzoic acid |
≤0.1% |
0.05% |
| USP Reference standards |
USP Procainamide Hydrochoride RS. |
Complies |
| Loss on drying |
≤0.3% |
0.12% |
| Residue on ignition |
≤0.1% |
0.03% |
| Heavy Metals(ppm) |
≤0.002% |
5ppm |
| Assay |
98.0~102.0% |
99.38% |
| Conclusion |
Qualified |
Procainamide Hydrochloride Application and side effects
Procainamide hydrochloride is used to treat ventricular arrhythmias: Ventricular Tachycardia and Tachycardia and Ventricular Arrhythmias: Atrial Fibrillation, Rehospitalization, and Automatic Supraventricular Tachycardia.
There are many side effects after procain amide induction. These adverse reactions are ventricular arrhythmias, bradycardia, hypotension and shock. If you increase the dose daily, side effects will be more serious. Procain amide can also cause fever and other allergic reactions in the drug. It is also possible that systemic lupus erythematosus can occur, leading to polyarticular pain, myalgia and pleurisy. Most of these side effects are caused by acetylation of procain amide.
Buy Procainamide Hydrochloride Powder
1. Minimum order quantity(MOQ): 10g
2. Payment way: Money Gram, Western Union, Bank Transfer and Bitcoin
3. Lead Time: Within 12hours after you payment
4. Delivery Time: 3-7 days door to door
5. Packing: Super discreet (hundreds to choose from)
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7. Tracking number: Available after parcel deliver out.
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