Methylxanthine Drug APIS Theophylline (1,3-dimethylxanthine) Powder For Sale
What is Theophylline?
Theophylline (1,3-dimethylxanthine) is a methylxanthine drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names. As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine and caffeine, and is readily found in nature, and is present in tea (Camellia sinensis) and cocoa (Theobroma cacao).
A small amount of theophylline is one of the products of caffeine metabolic processing in the liver.
Theophylline Basic Information
| Product Name |
theophylline |
| Alias |
Theophylline anhydrous; 1,3-dimethyl-3,4,5,7-tetrahydro-1H-purine-2,6-dione; dimethylxanthine |
| CAS NO |
58-55-9 |
| EINECS NO |
200-385-7 |
| MF |
C14H14NO2 |
| MW |
180.16 |
| Purity |
99% |
| Density |
1.62g/cm3 |
| Melting Point |
270-274ºC |
| Boiling Point |
390.1°C at 760 mmHg |
| Flash Point |
189.7°C |
| Solubility |
stored and protected from light |
| Appearance |
white crystalline powder |
| Package |
25 kg barrels |
Theophylline certificate Of Analysis
| Product name |
Theophylline(HPLC) |
| CAS No. |
58-55-9 |
Outer Packing |
25KG/drum |
| Production date |
14th Jan 2018 |
Shelf life |
13th Jan 2020 |
| Standard adopted |
Enterprise Standard |
| Items of analysis |
Specification |
Results |
| Appearance |
White Crystalline powder |
Complies |
| Odor |
Characteristic |
Complies |
| Related substances |
Total impurities NMT 0.5%
Any single impurity NMT 0.1% |
0.01%
0.01% |
| Identification |
Positive |
Complies |
| Residue on ignition |
NMT 0.1% |
0.03% |
| Assay |
NLT 99.0% Test By HPLC |
99.8% |
| Loss On Drying |
Hydrous NMT 9.5%
Anhydrous NMT 0.5% |
3.60%
0.03% |
| Conclusion |
Qualified |
Theophylline Main Action
1. relaxing bronchial smooth muscle
2. increasing heart muscle contractility and efficiency; as a positive inotrope
3. increasing heart rate: (positive chronotropic)
4. increasing blood pressure
5. increasing renal blood flow
6. anti-inflammatory effects
7. central nervous system stimulatory effect mainly on the medullary respiratory center.
Theophylline main therapeutic uses
asthma
infant apnea
chronic obstructive pulmonary disease (COPD)
Blocks the action of adenosine; an inhibitory neurotransmitter that induces sleep, contracts the smooth muscles and relaxes the cardiac muscle.
Theophylline side effects
Theophylline can also cause nausea, diarrhea, increase in heart rate, abnormal heart rhythms, and CNS excitation (headaches, insomnia, irritability, dizziness and lightheadedness). Seizures can also occur in severe cases of toxicity, and are considered to be a neurological emergency.
